Preheat oven to 375 degrees F (190 degrees C). Grease a 9x13-inch baking dish.
Cook macaroni according to package directions. Drain and set aside.
In a large bowl, whisk together evaporated milk, whole milk, melted butter, salt, and pepper.
Whisk in eggs one at a time, then stir in 3 cups of the cheddar cheese and 1 1/2 cups of the Gruyère cheese.
Add cooked macaroni to the cheese mixture and stir to coat.
Pour macaroni and cheese mixture into prepared baking dish.
In a small bowl, combine panko breadcrumbs and melted butter. Sprinkle over the top of the macaroni and cheese.
Bake for 20-25 minutes, or until golden brown and bubbly.
Let stand for 5 minutes before serving.
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Notes
For a richer flavor, use full-fat milk and cheese.If you don't have Gruyère cheese, you can substitute Parmesan cheese.To make this dish ahead of time, prepare the macaroni and cheese mixture according to the instructions above. Refrigerate overnight. Before serving, bake for 20-25 minutes, or until heated through.This mac and cheese can also be made in a slow cooker. Simply combine all of the ingredients in the slow cooker and cook on low for 4-6 hours, or until the macaroni is tender and the cheese is melted.